Crumble and cook sausage in a large skillet until cooked through. Transfer to a paper towel lined plate.
Add Bisquick, milk, eggs, salt, and black pepper to a large bowl or container sealed tightly. Whisk or shake until well combined.
Grease a 13"x9" baking dish with butter or nonstick cooking spray. To the prepared baking dish, layer sausage, onion, and cheese.
Pour the egg mixture evenly on top.
Either cover tightly with plastic wrap or aluminum foil and refrigerate over night or bake immediately. Next morning, allow the casserole to sit at room temperature for 15 minutes prior to baking.
Bake uncovered in a preheated 400ºF oven for 35-40 minutes. Cool 5 minutes before serving.
Optional garnishes: salsa, sliced green onions, or hot sauce.