Preheat the oven to 350ºF.
Microwave ¼ cup freshly squeezed orange juice for 15 seconds. Mix the cranberries with the juice and set aside.
To a gallon Ziploc bag, add sugar, salt, 1 tablespoon of the orange zest, and cinnamon. Close the bag, mix the until blended well, add the biscuit pieces, mix, add cranberries, and mix one last time. Pour the mixture into a parchment paper lined loaf pan.
In a medium pan over medium heat, melt the butter, brown sugar, and vanilla just until the sugar has dissolved. Pour over the biscuit pieces, making sure each piece is covered well.
Bake 25-30 minutes, or until the top of the biscuits are golden brown and dough is cooked through. Allow to cool 10 minutes then invert on a serving plate.
Optional Glaze: whisk together 1 tablespoon melted butter, ¼ cup powdered sugar, remaining 1 teaspoon orange zest, and 1 tablespoon orange juice. Drizzle on top of the loaf. ⠀